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Dehghan, Fatemeh, Salah, Zahra. (1404). The Impact of Transcranial Direct Current Stimulation (tDCS) on Memory Function in Older Adults with Mild Cognitive Impairment: A Systematic Review. , (), -. doi: 10.22059/jcsr.2025.400319.1016
Fatemeh Dehghan; Zahra Salah. "The Impact of Transcranial Direct Current Stimulation (tDCS) on Memory Function in Older Adults with Mild Cognitive Impairment: A Systematic Review". , , , 1404, -. doi: 10.22059/jcsr.2025.400319.1016
Dehghan, Fatemeh, Salah, Zahra. (1404). 'The Impact of Transcranial Direct Current Stimulation (tDCS) on Memory Function in Older Adults with Mild Cognitive Impairment: A Systematic Review', , (), pp. -. doi: 10.22059/jcsr.2025.400319.1016
Dehghan, Fatemeh, Salah, Zahra. The Impact of Transcranial Direct Current Stimulation (tDCS) on Memory Function in Older Adults with Mild Cognitive Impairment: A Systematic Review. , 1404; (): -. doi: 10.22059/jcsr.2025.400319.1016

The Impact of Transcranial Direct Current Stimulation (tDCS) on Memory Function in Older Adults with Mild Cognitive Impairment: A Systematic Review

Cognitive Science Research
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 31 شهریور 1404
نوع مقاله: Systematic Review
شناسه دیجیتال (DOI): 10.22059/jcsr.2025.400319.1016
نویسندگان
Fatemeh Dehghan* 1؛ Zahra Salah2
1Interdisciplinary schools, Iran, Tehran Islamic Azad University, Iran, Zarghan
2Azad Islamic university, Iran, Zarghan
چکیده
Background: Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and dementia, with memory impairment central. Global prevalence in adults ≥50 years is ~19.7%. Pharmacological treatments have limited efficacy; transcranial direct current stimulation (tDCS) is explored to enhance cognition by modulating cortical excitability.



Objective: Evaluate the effects of tDCS on memory in older adults with MCI and identify stimulation parameters linked to larger gains.



Methods: Systematic review of PubMed, Scopus, and Web of Science through April 2025, per PRISMA. Included randomized and non-randomized trials of tDCS alone or with cognitive training in adults ≥60 with MCI. Meta-analysis was precluded by heterogeneity; narrative synthesis reported. Ten studies (N=428) met criteria. Risk of bias assessed with the JBI RCT checklist.



Results: Verbal memory improvements were common (e.g., RAVLT in 3/5 studies, p<0.05) and recognition memory improved (p<0.001). Spatial memory also improved (WMS-RC; episodic latency, p<0.05). Neurophysiology showed ERP latency reductions (~27 ms), amplitude increases (~1.8 μV), and better fronto-parietal connectivity (r=0.59, p=0.02). Subgroups favored: left DLPFC stimulation (8/10 studies; g=0.42), ≥10 sessions (6/10; g=0.61), and 2 mA intensity (7/10; g=0.55). Mild adverse effects occurred in 20–30%; no serious events. Study quality ranged from moderate to low risk of bias (mean ~11/13).



Conclusion: Preliminary evidence supports tDCS, especially anodal left DLPFC at 2 mA for ≥10 sessions, to improve memory in MCI, with corroborating neurophysiological changes. Heterogeneity and small samples warrant cautious interpretation. Future work should standardize protocols, personalize via biomarkers, and use longitudinal designs.
کلیدواژه‌ها
Mild Cognitive Impairment؛ transcranial direct current stimulation؛ memory؛ aging؛ systematic review
آمار
تعداد مشاهده مقاله: 56





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