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Yari, Fatemeh, Sabaghi, Fatemeh, Bagheri, Nadia, Teimurpour, Amir, Zaman-Vaziri, Maryam, Mortezapour Barfi, Farzaneh, Sobhani, Maryam. (1404). Comparison Between HLA-B Allele Groups Among Peripheral Blood Stem Cell Donation Volunteers From Various Iranian Ethnicities. , (), -. doi: 10.22059/jsciences.2024.378778.1007869
Fatemeh Yari; Fatemeh Sabaghi; Nadia Bagheri; Amir Teimurpour; Maryam Zaman-Vaziri; Farzaneh Mortezapour Barfi; Maryam Sobhani. "Comparison Between HLA-B Allele Groups Among Peripheral Blood Stem Cell Donation Volunteers From Various Iranian Ethnicities". , , , 1404, -. doi: 10.22059/jsciences.2024.378778.1007869
Yari, Fatemeh, Sabaghi, Fatemeh, Bagheri, Nadia, Teimurpour, Amir, Zaman-Vaziri, Maryam, Mortezapour Barfi, Farzaneh, Sobhani, Maryam. (1404). 'Comparison Between HLA-B Allele Groups Among Peripheral Blood Stem Cell Donation Volunteers From Various Iranian Ethnicities', , (), pp. -. doi: 10.22059/jsciences.2024.378778.1007869
Yari, Fatemeh, Sabaghi, Fatemeh, Bagheri, Nadia, Teimurpour, Amir, Zaman-Vaziri, Maryam, Mortezapour Barfi, Farzaneh, Sobhani, Maryam. Comparison Between HLA-B Allele Groups Among Peripheral Blood Stem Cell Donation Volunteers From Various Iranian Ethnicities. , 1404; (): -. doi: 10.22059/jsciences.2024.378778.1007869

Comparison Between HLA-B Allele Groups Among Peripheral Blood Stem Cell Donation Volunteers From Various Iranian Ethnicities

Journal of Sciences, Islamic Republic of Iran
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 16 شهریور 1404
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22059/jsciences.2024.378778.1007869
نویسندگان
Fatemeh Yari* 1؛ Fatemeh Sabaghi2؛ Nadia Bagheri3؛ Amir Teimurpour4؛ Maryam Zaman-Vaziri5؛ Farzaneh Mortezapour Barfi4؛ Maryam Sobhani4
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran
2-Hematology Department, Faculty of Allied Medicine, Iran University of Medical Science, Hemmat Highway, Tehran, Iran. -Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
3Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
4Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
5Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
چکیده
Background and purpose: A total of 2064 individuals of hematopoietic stem cell donors from various ethnic groups in Iran were included in this study. The primary objective of this research was to establish an HLA database and determine the genetic diversity among different ethnicities.
Methods: DNA was extracted using the magnetic method. Subsequently, HLA-typing was conducted using the PCR-SSP method at a low-resolution level. Results were analyzed by independent experts, manually and via software. The HLA data from four different ethnicities, Gilak (n=510), Lor (n=465), Kurdish (n=719), and Arab (n=370), were examined for allele-ethnicity association. Allele frequencies were evaluated using statistical methods to determine any significant relationships. A significant level was set at 0.05. Additionally, standardized residuals were determined to identify the ethnicities in which the frequency of the studied alleles exceeded the expected values based on independence assumptions.
Results: HLA-B*35 and HLA-B*51 exhibited the most prevalent allelic frequencies among HLA-B allele groups. It is worth mentioning that HLA-B*67, *78, *81, *82, and *83 were not observed in our study. Additionally, significant differences were detected in 17 alleles across the ethnic groups studied for HLA-B, with a P-value less than 0.05.
Conclusion
Determining the frequency of HLA alleles can specify similarities and differences in allelic groups within different ethnicities. This identification can be effective in designing an efficient strategy for establishing donor services in Iran's diverse regions and in stem cell registries. In the future, this data could lead to new clinical applications in transplantation, vaccine development, and infectious diseases.
کلیدواژه‌ها
HLA؛ Hematopoietic Stem Cell؛ Donors؛ Ethnicity؛ Iran
آمار
تعداد مشاهده مقاله: 40





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