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Nik, Salar, Moslemi, Hamid Reza, Ahmadi-hamedani, Mahmood, Kafshdouzan, Khatereh. (1404). Exploring the Effects of Metformin on Chronic Non-Bacterial Prostatitis: Insights into Its Impact on IL-17, IFN-γ and Sperm Quality in Rat Model. , (), -. doi: 10.22059/ijvm.2025.386192.1005698
Salar Nik; Hamid Reza Moslemi; Mahmood Ahmadi-hamedani; Khatereh Kafshdouzan. "Exploring the Effects of Metformin on Chronic Non-Bacterial Prostatitis: Insights into Its Impact on IL-17, IFN-γ and Sperm Quality in Rat Model". , , , 1404, -. doi: 10.22059/ijvm.2025.386192.1005698
Nik, Salar, Moslemi, Hamid Reza, Ahmadi-hamedani, Mahmood, Kafshdouzan, Khatereh. (1404). 'Exploring the Effects of Metformin on Chronic Non-Bacterial Prostatitis: Insights into Its Impact on IL-17, IFN-γ and Sperm Quality in Rat Model', , (), pp. -. doi: 10.22059/ijvm.2025.386192.1005698
Nik, Salar, Moslemi, Hamid Reza, Ahmadi-hamedani, Mahmood, Kafshdouzan, Khatereh. Exploring the Effects of Metformin on Chronic Non-Bacterial Prostatitis: Insights into Its Impact on IL-17, IFN-γ and Sperm Quality in Rat Model. , 1404; (): -. doi: 10.22059/ijvm.2025.386192.1005698

Exploring the Effects of Metformin on Chronic Non-Bacterial Prostatitis: Insights into Its Impact on IL-17, IFN-γ and Sperm Quality in Rat Model

Iranian Journal of Veterinary Medicine
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 21 مرداد 1404
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22059/ijvm.2025.386192.1005698
نویسندگان
Salar Nik1؛ Hamid Reza Moslemi2؛ Mahmood Ahmadi-hamedani* 2؛ Khatereh Kafshdouzan3
1Student Research Committee, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
2Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
3Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
چکیده
Background: Chronic non-bacterial prostatitis (CNP) is a common, debilitating prostate disorder with no standardized treatment. Metformin, an anti-diabetic drug, exerts anti-inflammatory effects by reducing cytokines.

Objectives: This study investigated whether metformin (MET) could protect rats from carrageenan-induced chronic nonbacterial prostatitis (CNP).

Methods: Twenty-four eight-week-old male Wistar rats were selected and divided into four groups, including the mock group (Group I), CNP-control group (Group II), CNP-cernilton group (Group III), and CNP-MET group (Group IV). For CNP induction, 1% carrageenan (0.1 ml) was injected intraprostatic into groups II, III, and IV. The rats in groups III and IV received cernilton (100 mg/kg) and MET (100 mg/kg) orally for three weeks. Prostatic index (PI), serum prostate-specific antigen (PSA), interleukin-17 (IL-17), interferon- γ (IFN‐γ), and sperm parameters (counts, motility, and viability) were compared between groups. Data were analyzed using one-way ANOVA with Tukey's post-hoc test for normal distributions and Kruskal-Wallis with Mann-Whitney U test for non-normal distributions. Significance was set at P<0.05.

Results: There was a significant increase (p<0.05) in PI, serum levels of PSA, IL-17, and IFN‐γ in group II. At the same time, the sperm quality parameters were significantly decreased (P<0.05) in this group. On the other hand, in group IV, a significant decrease (P<0.05) in PI, PSA, IL-17, and INF- γ levels was observed, and sperm quality parameters improved compared to group II.

Conclusion: The present study's results showed that treatment with MET by reducing inflammatory cytokines such as IL-17 and IFN‐γ improved inflammation and sperm quality parameters in CNP rats.
کلیدواژه‌ها
Anti-inflammatory properties؛ Cytokine suppression؛ Interleukin-17 modulation؛ Sperm motility improvement؛ Intraprostatic intervention
آمار
تعداد مشاهده مقاله: 18





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