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Assessment of the Analgesic, Anti-inflammatory and Antipyretic Activity of Amitriptyline in Chicks | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 15 اردیبهشت 1404 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2025.386838.1005705 | ||
| نویسندگان | ||
| Abdeslam Saleh؛ Yasser Albadrany* | ||
| Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq | ||
| چکیده | ||
| Background: Amitriptyline is effective for pain alleviation in a variety of pain states because there is evidence that it influences various analgesic pathways. Objectives: This study aimed to determine the analgesic dose, analgesic effect over time, and anti-inflammatory and antipyretic effects of amitriptyline in chicks. Methods: Sixty-six broiler chicks were used in several successive experiments. Five and seven chicks were used to determine the median lethal dose (LD50) and median effective analgesic dose (ED50), respectively, using the Dixon method. Pain was induced and assessed using an electrical stimulator. Three sets of experiments were done for assessment of analgesic, anti-inflammatory, and antipyretic effects by using three groups of six chicks (control, amitriptyline 50 and 100 mg/kg BW, orally). A formalin test was used to induce acute inflammatory pain, and a baker’s yeast test was used to induce fever. Results: The LD50 and ED50 of oral amitriptyline were 315 mg/kg and 23 mg/kg, respectively. Amitriptyline showed short-term analgesic effects for periods lasting only two hours. Amitriptyline at 50 and 100 mg/kg showed dose-dependently significant analgesic and anti-inflammatory effects by reducing the number of foot lifting and thickness of the paw treated with formalin, respectively, compared to the control group. Amitriptyline showed a significant antipyretic effect, as the doses of 50 and 100 mg/kg were able to prevent the temperature rise for six and nine consecutive hours, respectively. Conclusion: The study concluded that amitriptyline had a short-term analgesic effect with an acute anti-inflammatory effect, with a remarkable effect on reducing the induced fever. | ||
| کلیدواژه‌ها | ||
| Amitriptyline؛ Analgesic؛ Anti-inflammatory؛ Antipyretic؛ Chicks | ||
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آمار تعداد مشاهده مقاله: 47 |
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